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Mechanistically, SeNPs reduce oxidative stress, alter apoptotic molecules, and improve the action of chemotherapeutic agents including doxorubicin, cisplatin, and paclitaxel, while also exhibiting activity against multidrug-resistant microorganisms including methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa , and Klebsiella pneumoniae

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Proceedings of the National Academy of Sciences 118 (34): e2025813118

SGLT2 inhibitors reduce the workload of the proximal tubules to improve tubulointerstitial hypoxia, and then allow fibroblasts to resume normal erythropoietin production, and thereby protect the kidney [30]