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The GLP-1 RAs were originally developed for the treatment of type 2 diabetes mellitus (T2DM), but they soon showed promising effects in weight reduction [1, 2]

The result is effective weight management and potential weight loss results that exceed those of other treatments

Weight loss without muscle preservation can leave people looking and feeling worse than when they started

Those patients who expect to experience weight loss through the use of Farxiga may find themselves frustrated

However, that is not the reality: even diabetic patients treated with GLP-1 RAs are more likely to stop them than other second-line anti-diabetic medicines

The trial enrolled 10,142 people (across CANVAS and CANVAS-renal [CANVAS-R]) with T2DM, either with prior symptomatic CV events or at least two risk factors for CVD [51, 65]