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Key factors affecting muscle preservation include: Baseline body composition : Individuals with higher initial muscle mass and lower body fat percentages may experience more pronounced muscle loss during weight reduction Protein intake adequacy : Insufficient dietary protein (below 0.8-1.0 g/kg/day, and ideally 1.2-1.6 g/kg of adjusted body weight for those losing weight) compromises muscle protein synthesis Physical activity levels : Sedentary behavior during treatment accelerates muscle catabolism, while resistance training provides protective stimulus Age : Older adults face greater risk due to age-related sarcopenia and reduced anabolic response to dietary protein Medication dosage and duration : Higher doses and longer treatment periods associated with greater total weight loss may potentially result in more absolute muscle loss, though this relationship requires further study The hormonal environment during weight loss also influences muscle preservation