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Its most cited wound-healing paper, Malinda et al., J Invest Dermatol 1999, showed that T4 increased re-epithelialisation by roughly 42% at four days and up to 61% at seven days in a full-thickness rat wound model, with greater collagen deposition and angiogenesis

The interaction between FOXO4 and p53 within the nucleus plays a crucial role in the survival of both normal and senescent cancer cells 25,34

By weeks 3-4, skin texture changes become more apparent

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