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Lean, metabolically healthy profiles use roughly 0.3 to 0.5 mg because exposure and heart-rate sensitivity are higher at the same nominal dose. These sub-1 mg ranges are modeled rather than outcome-tested

Identification of a steroid receptor on the surface of Xenopus oocytes by photoaffinity labeling

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For the other proposed uses (Crohn's, celiac, tendonitis), the agency found the effectiveness evidence similarly insufficient, and it noted multiple FDA-approved products already exist to treat UC

FEBS letters , 238 (2), 343346

Stopping because symptoms improved at week 2 means abandoning the protocol before the structural repair phase has completed