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M., Kynaston, L., Naseem, S., Proudman, E., & Laceby, D

Although N-acetylcysteine (NAC) directly influences the pool of extracellular cystine and intracellular cysteine via a series of plasmatic redox reactions, in order to be effective, intracellular cysteine precursors must be designed to enter erythrocytes rapidly and use high activity enzymes within erythrocytes to liberate cysteine (Whillier et al., 2009

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Plain glutathione is an extremely fragile molecule that is easily degraded and destroyed by bile and stomach acid

These reactions are typically transient, resolving within hours to a day or two