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Experimentally, excessive administration of MSG leads to elevated amounts of glutamic acid in the blood, resulting in glutamate overload that bypasses blood-brain barrier regulation, overactivating NMDA receptors, and triggering cascades that disrupt neuronal homeostasis 5,9

Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, et al

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What the Evidence Actually Shows, by Form On IV glutathione specifically: multiple systematic reviews and safety analyses single this route out as the one to avoid for cosmetic skin-lightening purposes the risk profile (including serious adverse events) isn't matched by convincing evidence of benefit, unlike oral or topical use

doi: 10.1172/JCI8376