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The timing of supply-related discontinuations further illustrates how external factors, like national shortages or surges in demand, can abruptly disrupt continuity of care ( 13 15 )

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423 The atherogenic, proinflammatory and prothrombotic properties of Lp(a) contribute to its role in ASCVD pathogenesis 424 Notably, 7090% of the serum Lp(a) concentration is genetically determined by the expression of the LPA gene 425,426 and is largely unaffected by diet and lifestyle modifications

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Sarkar S, Gough B, Raymick J, Beaudoin MA, Ali SF, Virmani A, Binienda ZK (2015) Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: neuroprotective effects of acetyl-l-carnitine

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Inconsistent dosing or inadequate rest periods may reduce effectiveness

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Interplay between insulin resistance and immune dysregulation in type 2 diabetes mellitus: implications for therapeutic interventions

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Krishnappa M, Patil K, Parmar K et al (2020) Effect of saroglitazar 2 mg and 4 mg on glycemic control, lipid profile and cardiovascular disease risk in patients with type 2 diabetes mellitus: a 56-week, randomized, double blind, phase 3 study (PRESS XII study)

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