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This hypothetical adverse effect, although not clinically reported until now, is analogous to the hypothalamic-pituitary axis suppression seen with long-term use of systemic corticosteroids Exacerbation of Helicobacter pylori associated peptic ulcers: Helicobacter pylori is known to feed on macrophages and neutrophils abundant at the site of inflammation caused by the ulcer

Higher doses (above 2mg/day) have not demonstrated proportional efficacy gains in published models and may increase copper ion toxicity risk

[PubMed] [Google Scholar] 91.Benison G.C., di Lello P., Shokes J.E., Cosper N.J., Scott R.A., Legault P., Omichinski J.G

Adverse reactions from all sources (clinical studies, literature and post-marketing) are listed in the table below by MedDRA system organ class

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This study will contribute to the literature