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What remains unknown Despite encouraging data, genuine unknowns exist: Effects beyond 6-9 months of continuous use have not been formally studied in animals or humans

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Disease activity was assessed utilizing the DAS28-CRP, a composite score that incorporates the count of tender and swollen joints, the patient's overall evaluation of disease activity, and the level of CRP

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others run continuous daily for a fixed block

These models demonstrate the distinct temporal and pathological progression of AD ike features, including tau abnormalities, intraneuronal A accumulation, and synaptic and neuronal loss, making them valuable tools for studying disease mechanisms and therapeutic strategies