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Second, enrolled populations differed substantially with respect to baseline cerebrovascular risk and clinical context (recent ACS in ELIXA vs chronic stable atherosclerotic disease vs mixed primary prevention in REWIND), which can alter stroke subtype distribution and the time course over which vascular risk modification translates into event reduction [44,46]

The prevalence of diabetes-associated microvascular complications across both cohorts was low (34%)

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Hemodialysis induces an acute decline in cerebral blood flow in elderly patients

Supplementation compensates for this deficiency and reduces inflammation

Am J Physiol Gastrointest Liver Physiol (2012) 303(7):G77585.10.1152/ajpgi.00155.2012 152 KawamataYFujiiRHosoyaMHaradaMYoshidaHMiwaMet alA G protein-coupled receptor responsive to bile acids