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This sample size provides at least 80% power for the comparison of tirzepatide versus placebo for the change in energy intake during ad libitum test meals (primary outcome) based on a two-sample t -test at an alpha level of 0.05, given an expected treatment difference of 212 kcal and an assumed common standard deviation of 289 kcal for the change in energy intake from baseline

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Based strictly on early trial comparisons, Retatrutide may achieve slightly greater weight loss (24% in 48 weeks) compared to Mounjaros 22% in 72 weeks

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All compounded medications are dispensed under licensed provider prescriptions through licensed compounding pharmacies