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Anyone taking oral antibiotics should avoid lying down immediately afterward to reduce the risk of esophageal irritation

This escalation is intentional

TABLET 11: It is advisable to take 1 tablet II daily in the evening, before going to bed.

When To Consult A Doctor Contact your doctor if you have: Severe or persistent vomiting Severe diarrhoea Signs of dehydration, such as very low urine, dizziness, or extreme weakness Severe abdominal pain, especially if it spreads to the back Yellowing of the skin or eyes Fever with abdominal pain Inability to pass stool or gas Repeated low blood sugar episodes Sudden vision changes Palpitations or a racing heartbeat at rest Swelling of the face, lips, tongue, or throat Breathing difficulty Severe rash or itching New or worsening depression Suicidal thoughts Symptoms before planned surgery or endoscopy If you are scheduled for surgery or a procedure under anaesthesia, tell your healthcare team that you are using a GLP-1 medicine

Stalmans S, et al

Cell 162 , 3344 (2015)