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doi: 10.1046/j.1526-4610.2003.03006.x 17

The liver X receptor (LXR) and hepatic lipogenesis

Marc Swiontkowski, MD JBJS Editor-in-Chief

Three pilot studies with very small sample sizes, a Phase II trial whose results remain unpublished, and a regulatory record that reflects the FDA's own assessment that sufficient human safety data do not exist that is the complete ledger as of 2025

However, the causality of this association remains uncertain, especially in European populations

Common symptoms include: Persistent fatigue and weakness Pale or jaundiced skin Heart palpitations and shortness of breath Nerve problems such as numbness or tingling Cognitive disturbances such as memory loss Glossitis and mouth ulcers High homocysteine levels, leading to cardiovascular issues Given the severe symptoms associated with Vitamin B12 deficiency, timely and effective treatment becomes essential