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Overall, GLP-1 RAs show potential benefits including reduced hospitalization, lower inflammatory markers, and effective weight loss, particularly in obese patients

doi:10.1152/ajpendo.00069.2016 Gupta NA, Mells J, Dunham RM, et al

When the thyroid is underactive, as in hypothyroidism, T3 and T4 are undersecreted, leading to a reduced metabolic rate and wide-ranging physiological consequences (Davis & Phillippi, 2022

The addition of GIP receptor activation was elegant in its simplicity and delivered tangible results

GLP-1 signalling remains largely intact in obesity and type-2 diabetes, while GIP signalling appears blunted, a finding that, paradoxically, did not deter Eli Lilly from pursuing GIP agonism in tirzepatide

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