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The findings identified a mechanism distinct from previously known appetite-control pathways as an avenue by which GLP-1s could treat other dysfunctions in reward processing, such as substance use disorder

The two agents work on different receptor systems amylin receptors and GLP-1 receptors respectively producing additive weight loss that exceeds what either drug achieves alone

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In cases where side effects are severe or intolerable, temporary dose reduction may be considered, with subsequent re-escalation attempted more gradually once symptoms have resolved