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A 2003 study by Staresinic, Sebecic, Patrlj, and colleagues in Journal of Orthopaedic Research used a rat Achilles tendon transection model with BPC-157 administered intraperitoneally once daily at 10 g/kg, 10 ng/kg, or 10 pg/kg and reported improved load-to-failure, Young's modulus of elasticity, and Achilles functional index scores, reduced tendon defect size by day 14, and increased tendocyte outgrowth in vitro with specific numerical effect sizes and p-values not reported in the abstract
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Mechanistically, we found that NRF2 is required for the deposition of H3K27ac marks at sites of nascent transcription, including eRNAs
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PML reported in patient receiving ocrelizumab
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