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SUSTAIN-6 specifically looked at cardiovascular outcomes including renal endpoints
Your individual potential depends on starting weight, genetics, and medication responsiveness
A physician may first review side effects, nutrition, hydration, constipation, protein intake, activity, current dose, medication consistency, and lab markers
When GLP-1 medicines may be beneficial A person may be suitable if they: Have strong appetite signals that make weight control difficult Have tried structured diet and activity plans without enough progress Have health conditions that improve when weight is reduced Need support managing portion sizes and cravings These treatments work best as part of a complete plan, not on their own
In the STEP 1 extension study, participants who stopped semaglutide after 68 weeks regained roughly two-thirds of their lost weight within a year