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MMP-9 is one of the elements contributing to the increase of BBB permeability

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Visceral and liver fat reductions are material over time, alongside improving lipid panels and insulin

134 Aged mice show a decrease in the reconstitution capability of their hematopoietic stem cells (HSCs), correlating with an increase in DNA damage 135,136 and with an increase in the levels of senescence effectors, such as p16INK4a