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While compounds like TB-500 are excellent for muscle and large tissue injuries, they lack the specific neuro-protective mechanism of ARA-290

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The global burden of ischemic heart disease is projected to rise dramatically, remaining the leading cause of cardiovascular death and accounting for a projected 20 million deaths by 2050 ( Oxidative stress represents a fundamental pathophysiological mechanism implicated in myocardial ischemia-reperfusion injury (MIRI) (Luo et al., 2023)

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Taken together, this evidence supports a decline in melatonin and an increase in oxidative stress during cognitive decline, independent of age

Antioxidants 12 , 974 (2023)