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This was recently demonstrated by Pan et al (2016) who show that low glutamine concentrations correlate with areas of low oxygen in xenograft tumours, resulting in histone hypermethlyation in these specific regions

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Group 2 showed a reduction of 13% when compared to baseline (mean 51.33 SD 22.86, 95% CI -11.77 to 27.02), but no significance (mean 51.33, 95% CI -34.62 to 3.45) (p=0.14) when compared to placebo