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(Most drugs, including aspirin, ibuprofen, and statins, are small-molecule drugs.) This makes orforglipron a promising new arrival on the weight-loss market, with the potential to democratise access to these important medications

[DOI] [PubMed] [Google Scholar] 39.Crane FL, Low H

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Gastrointestinal adverse events Very common (10% or more): Diarrhea (35%), abdominal pain (21%), vomiting (21%), nausea (12%) Common (1% to 10%): Constipation, dyspepsia, gastrointestinal disorder, melena Very rare (less than 0.01%): Abdominal cramps [Ref] Nervous system Very common (10% or more): Headache (37%), dizziness (18%), paresthesia (12%) Common (1% to 10%): Hypertonia, vertigo, taste perversion Frequency not reported : Seizures (with or without pre-existing seizure activity), increase in seizure frequency and/or severity [Ref] Metabolic Very common (10% or more): Hypercalcemia (15%), hypervolemia (12%) Common (1% to 10%): Anorexia, hyperkalemia [Ref] There are reports from clinical trials of significant hypertriglyceridemia associated with high doses of levocarnitine (3 g/day) given to uremic dialysis patients

In 2017, the first weekly GLP-1 agonist was approved to help type 2 diabetes

Can SLU-PP-332 be combined with other interventions in animal studies