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One is the mouse ear swelling test (MEST), which, like the guinea-pig methods described above, is based upon the evaluation of challenge-induced reactions in previously sensitized animals (Gad et al., 1986)

When skin is exposed to UV rays, it triggers melanocytes to produce more pigment, acting as a shield to prevent DNA damage

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10.1097/01.wcb.0000073905.87928.6d J

Tan A, Yang G, Wan X

Glia 54:116124 Lewerenz J, Maher P, Methner A (2011) Regulation of xCT expression and system xc function in neuronal cells