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Diabetes 66 , 22302240 (2017)

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DOI: 10.62211/82ej-91yt Liraglutide has a C16 palmitoyl fatty acid at lysine-26 via a short linker, binding albumin, extending its half-life from under 2 minutes to 11-15 hours, now allowing for once-daily dosing

The LEADER trial, for example, reported similar rates of breast cancer, prostate cancer, and other malignancies between liraglutide and placebo groups

While animal studies have not shown direct harm to offspring, the absence of human lactation studies means healthcare providers typically recommend delaying GLP-1 treatment until breastfeeding ends

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