The STEP PLUS trial published in The New England Journal of Medicine in 2024 examined the effects of semaglutide 2.4 mg weekly (the higher dose used for weight management, marketed as Wegovy) in adults with obesity and knee osteoarthritis
Also, it has not yet been studied in patients with history of pancreatitis, an issue with other GLP-1 agonists
La baisse du GSH est la fois une consquence et un amplificateur du vieillissement : l'accumulation de dommages oxydatifs rduit la capacit de synthse, tandis que la dpltion en glutathion laisse les cellules plus vulnrables aux agressions suivantes
Despite this shared mechanism, patient responses differ because the underlying biology is not uniform
Its a risk with absolutely no reward
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