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Understanding how GLP-1 regulates inflammation (Figure 1) provides insights into the pleiotropic weight lossindependent benefits of GLP-1R agonism, potentially explaining its actions to reduce the severity of several chronic diseases marked by dysregulated immune function and inflammation
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Source: Chang et al., 2020 Antioxidant and Anti-Inflammatory Action Alcohol generates massive oxidative stress
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Studies primarily conducted in rodents and primary cell culture have shown that carnitine supplementation may support the clearance of toxic byproducts of EtOH metabolism (acetate, fatty acid ethyl esters, reactive oxygen species), support oxidative metabolism, reduce the deleterious effects of ROS and inflammation in AUD, and support mitochondrial function and neurotransmitter synthesis in the brain
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Beyond synthesis, proper intracellular transport and distribution of CoQ after mitochondrial production is critical
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