Geoffs contributions were widely recognised
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Metformin In addition to potentially better blood glucose control, Ozempic is likely to cause more weight loss than Jardiance
These numbers represent the largest weight-loss magnitudes recorded in randomized phase 3 trials for this class of medication, approaching the efficacy historical patterns seen with surgical interventions like sleeve gastrectomy
Limitations and perspectives Therapeutic approaches targeting cardiac remodeling reversal, including monoclonal antibodies, peptide-based therapies, and AAV vectors, share similar translational challenges with cardiac regeneration strategies, particularly with respect to delivery efficiency and potential off-target effects
A safety signal emerged during clinical development: a separate obesity trial program using a related CJC-1295 compound was reportedly halted after a death, underscoring that long-term human safety is not established
