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However, clinical studies have shown that treatment with leptin or its analogues does not significantly affect body weight, fat mass, glucose and insulin homeostasis, lipid profile, or food intake in individuals with obesity compared to placebo [76,77,78,79]

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Studies have found that ALA exhibits anticonvulsant effects, and possible mechanisms may include altering membrane composition of nerve cells, activating PPAR and reducing inflammation (Reference Yamashita, Takahashi and Takashima3,Reference Rezaie, Nasehi and Vaseghi4)

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