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Wash cells in cold PBS

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If pralidoxime is administered before adequate atropinization , it may temporarily worsen life-threatening muscarinic effects, including: Bronchoconstriction Increased respiratory secretions , which can lead to airway obstruction Therefore, clinical guidelines recommend administering atropine before pralidoxime , and this sequence is reflected in autoinjector design (Aman et al., 2021

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5 Two factors drive this gap: Early discontinuation: About 22 % of semaglutide users and 16% of tirzepatide users stopped treatment within the first year, and many more quit after the one-year mark