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Disruptions in the NVU, leading to BBB dysfunction and reduced CBF, are early events in various neurodegenerative diseases, including AD, PD, and ALS [85]

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Subsequently, several studies were designed to shed light on this alarming association

Tirzepatide is also less effective at reducing body weight in T2D patients compared to patients without (15.7% weight loss, SURMOUNT-2 and 22.5% weight loss, SURMOUNT-1, respectively)

Since the mid-2000s, the structure of dipeptidyl peptidase-4 (DPP-4, CD26), an enzyme that decomposes GLP-1, has been discovered