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8 Stimulatory effect of glycine on human growth hormone secretion. National Center for Biotechnology Information

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Accordingly, in studies based on germ-free mice, a resistance to diet-induced obesity had been reported

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Recent Phase 3 data showed average weight reduction exceeding 28% in some participant groups after extended treatment periods

Factors that may influence long-term outcomes include: Treatment duration and adaptation : Some patients report symptom improvement with continued therapy as the body adjusts Weight stabilisation : As weight loss plateaus, biomechanical stress on muscles and joints typically normalises Physical conditioning : Patients who maintain regular physical activity often experience better musculoskeletal health Nutritional optimisation : Addressing any dietary imbalances can support muscle and joint function For patients who continue to experience troublesome body aches despite conservative management, alternative strategies may be considered in consultation with healthcare professionals