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17 Injured hepatocytes release soluble factors that activate HSCs to differentiate into myofibroblastic HSCs, as evidenced by cellular enlargement and proliferation, an increase in rough endoplasmic reticulum, loss of vitamin A droplets, expression of actin filaments, and increased expression of fibril-forming collagen types I, III, and V
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Most episodes of gastrointestinal events were mild or moderate and did not lead to discontinuation of therapy (6.2% with SAXENDA versus 0.8% with placebo discontinued treatment as a result of gastrointestinal adverse reactions)
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