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VEGF-induced antidepressant effects involve modulation of norepinephrine and serotonin systems

SASP factor levels should begin declining in tissues where clearance was successful

Systemic Healing Enhancement Healing time reductions reach 30-50% across various wound types, particularly effective for surgical wounds, chronic ulcers, and traumatic injuries

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Many community references include 2-4 week off-periods between cycles to allow fresh evaluation, although the rationale is community-derived rather than trial-validated

2014 Feb;13(1):8-12