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[5], [6], [7] Transcription factors of the FOXO family specifically FOXO1, FOXO3, FOXO4, and FOXO6 are key mediators of insulin and IGF signaling, participating in the regulation of a wide range of cellular processes, including metabolism, cell growth and differentiation, response to oxidative stress, autophagy, senescence, and aging-related processes

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American Journal of Gastroenterology, 112(5):775-784 Del Zompo, et al

Hyperpigmentation refers to areas of skin that become darker than the surrounding skin this can happen after acne heals (post-inflammatory hyperpigmentation), from sun damage (sun spots or age spots), or due to conditions like melasma

Taking less than the recommended amount might seem like it would reduce side effects, but thats not necessarily the case, according to Dr