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How much histamine is released determines the severity of symptoms

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Clinically BPH is manifested as lower urinary tract symptoms (LUTS) and consisting of voiding and storage symptoms such as slow urinary stream, splitting or spraying of urinary stream, recurrent urinary stream, straining to void and terminal dribbling, hesitancy, urgency, increased frequency, and incontinence

Vortioxetine also reduces QA in the cortex of murine lupus mice, an inflammatory model [197]

The type of treatment recommended will depend on factors such as overall health, the size of the enlarged prostate, and the severity of symptoms

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