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They exhibit different subcellular localizations: SIRT1, SIRT6, and SIRT7 are nuclear (although SIRT1 isoforms were also identified in the cytoplasm)

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Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study

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