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These effects include neurotrophic, neurogenic, neuroprotective, anti-inflammatory, and insulin sensitizing actions, a field currently under intensive investigation and not yet fully understood

GLP-1R is expressed by various populations of central neurons, but it is still not fully clear which specific populations mediate the effects of GLP-1RAs

An individualized approach considering medical history, current health status, and treatment goals is essential for the best outcomes

Subsequently, the IL-10 receptor/STAT3 signaling pathway in microglia is autocrinally activated, thereby promoting the expression and release of -endorphin, the latter acts on -opioid receptors on neurons to produce analgesic and neuroprotective effects (103105)

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