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This NADPH is likely supplied by the activity of Ald6 an aldehyde dehydrogenase which has previously been shown to be critical in the absence of a functional pentose phosphate pathway (Grabowska and Chelstowska, 2003)

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Various posttranslational modifications such as nitrosylation, hydroxylation, and glutathionylation are involved in stress signaling

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Some human studies within the broader context of peptide bioregulator research also suggested improved immune markers in elderly subjects