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Receptor binding affinity, intrinsic activity, and duration of receptor occupancy all influence downstream signaling

To elucidate potential mechanisms, the plasma metabolome of LC patients was investigated and compared to age-sex-matched acutely ill COVID-19, R, and HCs

doi: 10.7554/eLife.15092 21

GHK-Cu downregulates inflammatory cytokines, reduces the activity of pro-inflammatory signaling cascades, and modulates p38 MAPK in a way that reduces inflammatory response without suppressing the growth factor signaling needed for tissue repair

Not only that, the human body eliminates unused vitamin C, making it difficult to maintain normal concentrations for long periods of time 4

However, it is difficult to separate these two aspects in the current study design