273 Prions Prion diseases are neurodegenerative conditions represented by Creutzfeldt Jakobs disease, Gerstmann-Strussler-Scheinker syndrome, fatal familial insomnia, and Kuru disease
Mulhall J.P., Trost L.W., Brannigan R.E., et al
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However, persistent or intractable hiccupsdefined as lasting more than 48 hourscan indicate an underlying medical problem and warrant clinical evaluation
( The safety profile of liraglutide in our cohort was consistent with previous pediatric randomized controlled trials (RCTs), with adverse events (AEs) predominantly mild and gastrointestinal in nature, including nausea, vomiting, and diarrhea, reported in 43.6% of participants ( Despite these favorable outcomes, the discontinuation rate during the dose-escalation phase was relatively high (25.6%), mirroring patterns observed in other pediatric liraglutide trials where treatment withdrawal often occurred during the initial weeks, coinciding with peak gastrointestinal symptoms ( A key strength of this study lies in its conduct within a publicly funded healthcare system, entirely independent of pharmaceutical industry sponsorship, thereby enhancing both methodological rigor and external validity