Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023
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403.9 g/mol Peptide Length: 3 amino acids Purity: 99.0% (validated by Certificate of Analysis) Appearance: Blue to blue-green lyophilized powder Solubility: Fully soluble in water (HO) Quality Verification: Confirmed by RP-HPLC analysis Storage Conditions: Store dry at 28 C
Overall, given the thorough characterization of tirzepatide PK over a wide dose range from 0.5 to 15 mg at single-dose levels and under steady-state conditions, in which PK were observed to be linear and dose-proportional [27, 28], these increases of approximately 25% observed in this study are not considered clinically relevant
Wiviott, S
Of course, years of studies and testing were required well before its approval in 2005
