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First, they have a high permeability to Ca 2+ (although they are also permeable to Na + and K + ), and when they open significant increases in the level of Ca 2+ can be detected in the neuron (Figure 13.10)

doi: 10.1038/233058a0

Research Background In preclinical research settings, DSIP has been examined across laboratory models, often in the context of: Neuropeptide and hypothalamic signalling studies Sleep-wake cycle and circadian rhythm research models Stress-response and neuroendocrine pathway investigations Published research summaries and references can be accessed via public scientific databases such as PubMed

The graph highlights two important features of paracetamol toxicity

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Hepatology 43 , 723728 (2006)