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In the absence of insulin, IGF-I is necessary for human pluripotent stem cell maintenance (Wang et al.)

Mitochondrial Biogenesis and Exercise: Lpez-Lluch, G., et al

For instance, its extract significantly inhibits the lipopolysaccharide (LPS)-induced transcription of inflammatory cytokines (TNF-, IL-1 and IL-6) in RAW 264.7 cellsa well-established in vitro model for innate immune screening (Zhao et al., 2021)

For example, a daily dose of 500-1000 mcg might work for mild symptoms

The rise in cortisol can cause side effects such as joint pain and water retention