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Nausea, vomiting, diarrhea, and constipation are frequently reported, especially during initial dose escalation phases

Both insulin-resistance, which hampers fat oxidation, and the use of certain antidiabetic medications like insulin and sulfonylurea promote weight gain and might counteract the effects of anti-obesity medication (4850)

Before your body can use it, NAD+ has to be broken down into smaller building blocks outside the cell

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Stop or switch in consultation with your prescriber if any of the following appear despite hitting the 7 rules above: hand-grip strength drops more than 10% from baseline, you cannot climb one flight of stairs without significant fatigue, a 6-month DEXA shows more than 25% of total weight loss as lean mass, or you are losing more than 1.5% of bodyweight per week despite eating 1.6 g of protein per kilogram