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After 52 weeks of treatment, the researchers found that: Those taking the highest dose of orforglipron lost 9.2% of their body weight on average

Diabetes 30 (5), 321331

A 2025 Frontiers in Physiology study demonstrated that MOTS-c restores mitochondrial respiration in type 2 diabetic hearts

Some peptides are also available in nasal spray form or as peptide capsules , though bioavailability typically decreases with non-injectable routes

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