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GLP-1 peptides fail on all three counts
This effect is not observed in other GLP-1RAs and is currently being studied by the drug manufacturers in the FOCUS trial (NCT03811561)
Studies show that they can improve insulin sensitivity, helping to stabilize blood sugar levels and prevent insulin spikes
According to studies, the reduced incretin effect in patients with T2DM may be due to a decrease in the response of -cell to GIP and/or GLP-1 or a decrease in GLP secretion [15, 18, 27, 28]
doi: 10.1016/S0021-9258(18)42531-8 84 ChenYEDruckerDJ
It is a metabolic organ, a glucose sink, a functional reserve, and a major determinant of independence with aging
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