Moreover, analytical SEC suggests that SnCE1 Y212A is properly-folded, however, in contrast to non-acetylated SnCE1 C256A it elutes as sole monomer indicating the mutation affects the oligomeric state (Supplementary Fig
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In contrast, aged animals exhibited no significant changes in macrophage cytokine levels, suggesting that Epitalons therapeutic value may lie more in correcting age-related immune deficits than in stimulating already functional systems
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