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However, most studies indicate that the activation of hepatic stellate cells is an entry ticket to the process of liver fibrosis, resulting in the massive release of a variety of inflammatory factors, cytokines and oxidative stress responses

PIO, GLP-1R agonists, SGLT2 inhibitors and NAFLD: pathophysiological background PIO PIO, currently the only thiazolidinedione (TZD) in clinical practice, is a potent exogenous agonist of the nuclear peroxisome proliferator-activated receptor-gamma (PPAR-) and to a lesser extent, PPAR- [17, 44]

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The mechanisms of GSH transport into the mitochondria and the endoplasmic reticulum have not been established