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Research-grade materials serve as experimental substances and dont meet the same rigorous purity standards required for pharmaceutical-grade compounds

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For example, in cultured endothelial cells, lipoic acid was found to inhibit IKK-, an enzyme that promotes the translocation of redox-sensitive and pro-inflammatory transcription factor, nuclear factor-kappa B (NFB) from the cytosol to the nucleus (46)

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In theory, the difference in the effects might be attributed to a limited set of upstream and downstream effector proteins in erythrocytes compared with nucleated cells [84]