Its weight loss effects are likely due to several combined actions, including appetite reduction, increased fullness, glucose regulation and changes in energy balance
Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
Additional indications under investigation include type 2 diabetes, metabolic dysfunction-associated steatohepatitis (MASH), and potentially cardiovascular risk reduction
Important: Prescription weight loss medications and endoscopic procedures are not appropriate for every patient
Individuals who stopped using GLP-1RAs were categorized into interruption and discontinuation groups
Whilst retatrutide targets GLP-1, GIP, and glucagon receptors to reduce appetite and increase energy expenditure, cagrilintide acts via the amylin receptor pathway a distinct hormonal axis